Research Article
Clinical, Electrical and Therapeutic Aspects of Epilepsies with Centro-Temporal Spikes (EPCT): Before 3 Years Versus EPCT from 3 Years
Anna Modji Basse*,
Zeina Joubaily,
Halladain Mpung Mansoj,
Adjaratou Dieynabou Sow,
Marie Emilie Ndong,
Seynabou Dieng,
Lala Bouna Seck,
Moustapha Ndiaye,
Amamdou Gallo Diop
Issue:
Volume 7, Issue 4, December 2023
Pages:
77-81
Received:
3 October 2023
Accepted:
20 October 2023
Published:
9 November 2023
Abstract: Introduction: Centro-Temporal Spike Epilepsy (CTEP) is one of the idiopathic partial epilepsies of children. However, it can present atypical manifestations such as an early age of onset of seizures before 3 years of age. The objective of this work was to evaluate the clinical, paraclinical and therapeutic factors of EPCT before the age of 3 years versus EPCT from 3 years of age. Patients and method: We conducted a retrospective study between January 2005 and January 2021, covering children followed for EPCT at the Albert Royer Children's Hospital and at the Ibrahima Pierre Ndiaye Neuroscience Clinic of the Fann University Hospital Center. Results: 189 children were collected, among them, 154 started their seizures at the usual age from 3 years old (EPCTh group) while 35 started their seizures early before the age of 3 (EPCTp group). The average age was 5.22 +/- 3.71 (range 3 months and 12 years). The male gender predominated in both groups. Familial epilepsy was found in 37.5% of patients with EPCTp and in 30.1% of EPCTp patients. Parental consanguinity was 20% in the EPCTp patient group and 17.5% in the EPCTp patients. School difficulties were present in 55.6% of EPCTp patients and in 29% of EPCTh patients. The number of repetitions was 33% among EPCTp and 15.9% among EPCTh. The most frequent types of seizures were hemicorporal CPM (42.4%) in the EPCTp group, and CGTC (38.8%) in the EPCTh. Physical examination was normal in most cases. The majority of EEG abnormalities were Rolandic spikes. Imaging could only be performed in a few patients and came back normal in these cases. The majority of patients were on monotherapy with 69.7% of EPCTp and 52.2% of EPCTh under VPA and 27.3% of EPCTp and 44.2% of EPCTh under PB. The PB had 25% treatment failure and the VPA 33%. Among EPCTp, 5.7% progressed to POCS and 9.7% among EPCTh. Conclusion: EPCT is known for its usually favorable evolution, however we note that the more serious the history, the earlier the appearance of the first attacks will be. The challenge lies in the knowledge and proper management of these risk factors in order to avoid the occurrence of early onset crises.
Abstract: Introduction: Centro-Temporal Spike Epilepsy (CTEP) is one of the idiopathic partial epilepsies of children. However, it can present atypical manifestations such as an early age of onset of seizures before 3 years of age. The objective of this work was to evaluate the clinical, paraclinical and therapeutic factors of EPCT before the age of 3 years ...
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Research Article
Continuous Theta Burst Transcranial Magnetic Stimulation in Treating Post-Stroke Insomnia Monitored by Polysomnography: A Case Report
Li-min Zhong,
Hong Wang*,
Yan-hong Dai,
Yue-ting Deng,
Yi-qi Cao,
Ke-yi Chen,
Gang Wang
Issue:
Volume 7, Issue 4, December 2023
Pages:
82-85
Received:
8 October 2023
Accepted:
26 October 2023
Published:
9 November 2023
Abstract: The incidence of stroke has been increasing in recent years, and post-stroke insomnia, a common complication, also bothers many stroke patients. Post-stroke insomnia not only affects the quality of sleep and daily functioning of stroke patients, but it can also impacts stroke recovery and potentially lead to anxiety and depression disorders. This case report presents the case of a 47-year-old man who exhibited symptoms of early awakening, easy awakening, and daytime fatigue after suffering from a hypertensive cerebral hemorrhage. These symptoms occurred more than three times per week and persisted for six months. After giving treatments such as acupuncture and medication, this patient's sleep quality did not significantly improve. Considering the availability of noninvasive brain stimulation techniques, we opted to utilize continuous theta burst stimulation for the patient’s treatment. The stimulation was administered to the dorsolateral right frontal lobe, with an intensity set at 30% of resting motor thresholds. The treatment spanned 10 days, with one session per day lasting 48seconds. Following a single session, the patient's sleep quality and sleep structure showed improvement, and he did not experience any discomfort during this treatment. In conclusion, continuous theta burst stimulation proves to be an effective and safe therapeutic approach for patients with post-stroke insomnia.
Abstract: The incidence of stroke has been increasing in recent years, and post-stroke insomnia, a common complication, also bothers many stroke patients. Post-stroke insomnia not only affects the quality of sleep and daily functioning of stroke patients, but it can also impacts stroke recovery and potentially lead to anxiety and depression disorders. This c...
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Research Article
The Therapeutic Role of Flavonoids for Alzheimer's Disease
Jinchi Wei,
Zichun Liu,
Chiming Wei*
Issue:
Volume 7, Issue 4, December 2023
Pages:
86-96
Received:
5 October 2023
Accepted:
15 November 2023
Published:
17 November 2023
Abstract: Background: Alzheimer’s disease (AD) is the most common neurodegenerative disease characterized with mainly cognitive impairments, and the number of elderly having AD is continuously increasing. Objective: To summarize the pathogenesis of AD and the therapeutic effects of flavonoids on related inflammatory processes. Main ideas: Flavonoids have been shown to alleviate effects of AD both in vitro and in vivo. Conclusion: The clinical significance of these research summaries lay a potential groundwork for the development of new drugs targeting AD treatment.
Abstract: Background: Alzheimer’s disease (AD) is the most common neurodegenerative disease characterized with mainly cognitive impairments, and the number of elderly having AD is continuously increasing. Objective: To summarize the pathogenesis of AD and the therapeutic effects of flavonoids on related inflammatory processes. Main ideas: Flavonoids have bee...
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