-
Clival Chordoma, Arising in Pre-existing Benign Notochordal Cell Tumor, Case Report
Maryam Almurshed,
Lamia Alsarraf
Issue:
Volume 7, Issue 1, March 2023
Pages:
1-4
Received:
23 December 2022
Accepted:
30 January 2023
Published:
9 February 2023
Abstract: Lesions of notochordal origin are unusual surgical cases that have a broad spectrum of differentiation, from remnants to benign tumors -namely “benign notochordal cell tumor BNCT”- to malignant chordoma. These lesions arise within the vertebral bodies at the ends of axial skeleton, clivus and lumbar areas. Chordoma, is a malignant destructive lesion extending from bone to surrounding soft tissue. It is hypothesized to arise from its rare benign counterpart, BNCT as evidenced by their co-existence in rare case reports, in lumbar area, an even more rare in clival region. These benign forms are even scarce to see in surgical pathology specimen and carry a histological resemblance in morphology to malignant chordoma if not recognized. Here, we report a case of chordoma arising from a benign notochordal cell tumor (BNCT), which was discovered in a 35 years old male who presented with diplopia, diagnosed as 6th nerve palsy. MRI imaging showed an expansile clival lesion with sclerotic borders invading the cavernous sinus and encasing the carotid. Histopathology showed features of chordoma within BNCT. This case highlights the rarity of the entity especially in the clival region, the wide differential diagnosis of clear cell tumor arising in the clival region and the importance of radio-pathological correlation.
Abstract: Lesions of notochordal origin are unusual surgical cases that have a broad spectrum of differentiation, from remnants to benign tumors -namely “benign notochordal cell tumor BNCT”- to malignant chordoma. These lesions arise within the vertebral bodies at the ends of axial skeleton, clivus and lumbar areas. Chordoma, is a malignant destructive lesio...
Show More
-
Quantity Processing in Object Counting Task Based on Event-Related Potentials
Chenming Sun,
Liyan Cui,
Yifeng Yan,
Yaru Shang,
Zhuoming Chen
Issue:
Volume 7, Issue 1, March 2023
Pages:
5-12
Received:
11 January 2023
Accepted:
6 February 2023
Published:
16 February 2023
Abstract: In the preliminary event-dependent potentials study, our team found that the neural mechanism of Chinese singular and plural picture naming is different, and explained that the differences might lie in the different numbers of quantitative processing. However, previous studies have lacked separate neural processing of objects in singular-plural pictures. This study intends to explore the neural differences in quantity processing in singular and plural pictures by using an object counting task and combining Event-related potential (ERP). It is expected to prove that the neural differences of naming Chinese single and plural pictures found in our previous ERP research are neural processing differences of different quantities, further demonstrating that the quantity processing in Chinese singular and plural picture naming is automatic. The experimental results showed no significant differences in object counting accuracy (P=0.139) and reaction time (P=0.231) between the singular and plural groups. However, there was a noticeable difference in ERPs between the two groups (P<0.05) and statistical analysis showed that the P1 effect of the parieto-occipital lobe was greater in plural pictures than in singular pictures (140-180ms) and the P2 effect of the parieto-occipital lobe was more significant in singular pictures than in plural pictures (200-320ms). There are differences in the quantity processing of healthy adults in object counting tasks. These differences are similar to the neural differences in Chinese singular-plural picture naming, indicating that the quantity is automatically processed in this process.
Abstract: In the preliminary event-dependent potentials study, our team found that the neural mechanism of Chinese singular and plural picture naming is different, and explained that the differences might lie in the different numbers of quantitative processing. However, previous studies have lacked separate neural processing of objects in singular-plural pic...
Show More
-
Non Vitamin k Antagonist Oral Anticoagulation Assessment in Non Valvular Atrial Fibrillation Using Transcranial Doppler Ultrasonography
Mohamed Ahmed Zaki,
Hamouda Abdel Khalek El-Bahnasy
Issue:
Volume 7, Issue 1, March 2023
Pages:
13-17
Received:
17 February 2023
Accepted:
8 March 2023
Published:
20 March 2023
Abstract: Background: Warfarin with optimized international normalization ratio (INR); is significantly affect the Micro embolic signals (MES), in many studies. Non vitamin k antagonist oral anticoagulants (NOACs) are recently approved for stroke prevention in non valvular AF. In contrast to Warfarin; effect of NOACs on MES is not yet fully researched. Aim: To determine the effect of NOACs on MES, in comparison to warfarin in non valvular AF, to reflect the potential embolization risk. Methods: The incidence and number of MES was studied in patients with non valvular AF. Two groups in the current study; the first, patients were put on warfarin with INR levels were optimized to (2-3), and considered as a control group. The second; patients were put on NOAC (rivaroxaban, 15 mg /day). Study patients were recruited from cardiology outpatient clinics and departments (Al-Azhar University hospitals; Cairo and New Damietta, Egypt). Patients of the both groups were subjected to MES detection and counting by transcranial Doppler ultrasonography (TCD) monitoring. Results: MES did not detected in 22.5% in study groups; no statistically significant differences between study groups. The incidence and number of MES; within the warfarin group; MES were detected in (30 patients, 75%), while within the rivaroxaban group (32 patients, 80%). The average number of MES; in group one were (11.65 ±7.20), and in group two (11.50 ±7.20), with no significant statistical difference also. Conclusion: The effect of warfarin and NOAC use is not statistically different and Rivaroxaban is not inferior to warfarin.
Abstract: Background: Warfarin with optimized international normalization ratio (INR); is significantly affect the Micro embolic signals (MES), in many studies. Non vitamin k antagonist oral anticoagulants (NOACs) are recently approved for stroke prevention in non valvular AF. In contrast to Warfarin; effect of NOACs on MES is not yet fully researched. Aim: ...
Show More
